Targeted Therapies Improve Outcomes in Renal Cancer and GIST, but Challenges Remain

Targeted therapies have significantly changed the treatment of cancer and are now considered to be a component of care for a number of common malignancies, including breast, colorectal, and lung cancers. In particular, they have significantly improved outcomes for patients with metastatic renal cell carcinoma (mRCC) and advanced gastrointestinal stromal tumors (GIST).

Byetta Linked to Acute Pancreatitis

Six new cases of hemorrhagic or necrotizing pancreatitis have been reported in patients using exenatide injection (Byetta, Amylin Pharmaceuticals, Inc), the US Food and Drug Administration (FDA) advised healthcare professionals today.

Factor VII Curbs Bleeding in Non-Hemophiliac Trauma, Surgical Patients

Use of recombinant activated factor VII (rFVIIa) reduces the need for blood transfusion in patients without hemophilia and may also reduce mortality, according to pooled data from randomized placebo-controlled trials involving more than 3000 participants, Canadian researchers report.

First Heart Transplants in Children Following Donor Cardiac Death

US doctors have reported the first experiences of heart transplant in three infants after cardiocirculatory death, rather than brain death, in the donors [1]. Lead author Dr Mark M Boucek (Joe DiMaggio Children's Hospital, Hollywood, FL) told heartwire this was, to his knowledge, the first published account of heart transplant in children after donor cardiac […]

FDA unexpectedly rejects Schering anesthesia drug

Schering-Plough Corp (nyse: SGP – news – people ) said Friday U.S. regulators had rejected Bridion, its drug to reverse the effects of anesthesia that had been heralded as a breakthrough product by analysts and was unanimously recommended by a federal advisory panel.