Llatest News

Models Predict Success With Growth Hormone Treatment

Mathematical models, particularly those incorporating both growth and endocrine data, can predict which short children will benefit from treatment with growth hormone (GH), according to a new study.


The study, published online in BMC Medical Informatics and Decision Making, built on previous research by incorporating a broader range of data and by evaluating children who were appropriate for gestational age (AGA) as well as those who were small for gestational age (SGA).

Using growth data from 415 short prepubertal children, researchers at the University of Gothenburg, Sweden, constructed mathematical models to predict growth response during the initial years of GH therapy. Endocrine investigations performed prior to GH treatment included a GH stimulation test (the arginin insulin tolerance test). In addition, a spontaneous 24-hour GH profile was obtained for 188 children, and serum leptin and insulin-like growth factor I (IGF-I) levels were measured in samples from 200.

The children in the study group, treated between 1986 and 1997, received a daily dose of GH ranging from 25 to 66 g/kg. Of the 415 children, 271 had been born AGA and 144 had been SGA. Additionally, isolated idiopathic GH deficiency was present in 280.

The predictive model using only growth data yielded a standard error of the residuals (SDres) of 0.23. The models adding endocrine data, however, brought the SDres down, to 0.15 in the case of the model incorporating 24h GH profile, IGF-I and leptin. This corresponds to a prediction interval of 1.2 cm in a 4-year-old boy.

The researchers noted that if a spontaneous GH profile is not possible, IGF-I and leptin data are still valuable.

Validation of the models with a separate cohort of 112 children showed results similar to those in the study group. These children, subjected to the same inclusion criteria as the study group, received GH therapy from 1998 to 2001, after recruitment for the study had closed.

"The models presented here are independent of birth size and provide the highest prediction accuracy available," the researchers write. "They serve as a tool to identify those children who may benefit from GH treatment, and to help choose the optimal GH dose during the first years of treatment in order to optimize the individual catch-up growth response."

BMC Medical Informatics and Decision Making 2007;7:40.

Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident… sunt in culpa qui officia deserunt mollit anim id est laborum. Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam, eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt. Lorem ipsum dolor.
“Quis autem vel eum iure reprehenderit qui in ea voluptate velit esse quam nihil molestiae consequatur, vel illum qui dolorem eum”
– Litza Braun

Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident. sunt in culpa qui officia deserunt mollit anim id est laborum. Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam

Explore the diverse landscape of literature

At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas molestias excepturi sint occaecati cupiditate non provident, similique sunt in culpa qui officia deserunt mollitia animi, id est laborum et dolorum fuga. Et harum quidem rerum facilis est et expedita distinctio.

Ut enim ad minima veniam, quis nostrum exercitationem ullam corporis suscipit. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id totam rem aperiam, eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt.

Neque porro quisquam est, qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit, sed quia non numquam eius modi tempora incidunt ut labore et dolore magnam aliquam quaerat voluptatem. Ut enim ad minima veniam, quis nostrum exercitationem ullam corporis suscipit. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. 

Eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt. Neque porro quisquam est, qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit sed.
Post Tags :
&quot, and, children, data, endocrine, group, growth, igf, incorporating, leptin, models, predict, profile, researchers, study, therapy, those, treatment, were, with
Share This :

Leave a Reply

Your email address will not be published. Required fields are marked *

Gina Gagua

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.